Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum
نویسندگان
چکیده
منابع مشابه
Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.
Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal forms of human malaria, is exposed to radically different environments and stress factors during its complex lifecycle. In any organism, Hsp70 chaperones are typically associated with tolerance to stress. We therefore reasoned that inhibition of P. falciparum Hsp70 chaperones would adversely affect parasite...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2009
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2009.01.024